The Twin Midtown Comedy Open Mics A comedy open mic upstairs at Midtown Bar & Grill on West Grey in Houston, TX every Wednesday and Friday at 9:30 pm. First-timers, stand-up comedy fans, and all Houston comics are more than welcome. Bar-backed and spacious w/ plenty of seats to see locals try their hand at making you laugh. It's free. Sign-up and perform. 5 minutes each. Countdown timer provided.